Evaluation of the Epidermal Langerhans Cell Population in AIDS / ARC Patients by the Topical Application of a Potent Contact Allergen (1-Chloro-2,4-Dinitro-Chlorobenzene) (DNCB)

University of California San Francisco (UCSF) logo

University of California San Francisco (UCSF)

Status

Completed

Conditions

HIV Infections

Treatments

Drug: Dinitrochlorobenzene

Study type

Interventional

Funder types

Other

Identifiers

NCT00002031
047A

Details and patient eligibility

About

To evaluate the effect of application of Dinitrochlorobenzene (DNCB) on the number, morphology, and antigen expression of epidermal Langerhans cells in AIDS and AIDS related complex (ARC) patients.

Sex

All

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

Patients must have the following:

  • Stage III or IV HIV infection.
  • Provide informed consent.

Exclusion Criteria

Co-existing Condition:

Patients with the following conditions or symptoms are excluded:

  • Kaposi's sarcoma lesions in the proposed treatment sites.
  • Liable to require radiation or chemotherapy during the course of the study.
  • Not likely to survive the length of the study.
  • Obvious ultra-violet-irradiated skin damage in the treatment areas and anyone with recent UV exposure or likely to have such exposure (e.g.:
  • holiday tans obtained in Hawaii, members of UV box tanning salons, etc.) Allergy to lidocaine.

Concurrent Medication:

Excluded:

  • Other Immunomodulators.

Concurrent Treatment:

Excluded:

  • Radiation.

Patients with the following are excluded:

  • Kaposi's sarcoma lesions in the proposed treatment sites.
  • Liable to require radiation or chemotherapy during the course of the study.
  • Not likely to survive the length of the study.
  • Obvious ultra-violet-irradiated skin damage in the treatment areas.
  • Allergy to lidocaine.

Prior Medication:

Excluded:

  • Prior DNCB therapy.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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