Evaluation of the Impact of Red Blood Cell Exchange on Thrombo-inflammation in Sickle Cell Disease (STIREX)

Toulouse University Hospital

Status

Not yet enrolling

Conditions

Sickle Cell Disease

Treatments

Other: Red blood cell exchange

Study type

Observational

Funder types

Other

Identifiers

NCT06769139

RC31/24/0509

Details and patient eligibility

About

Sickle cell disease is the most common inherited blood disorder worldwide. It is a hemoglobinopathy characterized by chronic hemolysis, endotheliopathy, coagulation activation, and chronic inflammation. It is a multisystemic disease leading to acute (vaso-occlusive crisis, acute chest syndrome, stroke...) and chronic complications with multiorgan damage. Thrombo-inflammation is defined by the cooperation and interaction between hemostasis and the innate immune system. The platelet represents the cornerstone of this phenomenon, being at the interface of these two systems. In sickle cell disease, platelets are activated and release cytokines, leading to a pro-coagulant and pro-inflammatory state. Transfusion, whether occasional or chronic, is a major sickle cell disease treatment. It is common to distinguish simple transfusion from exchange transfusion. The latter involves replacing a given volume of sickle red blood cells with healthy red blood cells. Exchange transfusion allows avoiding an excessive increase in hemoglobin. The decrease of hemoglobin S under 30% achieved by red blood cell exchange reduces the risk of stroke by more than 90% in children with cerebral vasculopathy. Moreover, transfusion can be used in acute complications such as vaso-occlusive crisis and acute chest syndrome. Despite this efficacy, a subgroup of patients is not totally protected against acute and chronic complications. The persistence of chronic inflammation is suggested. To date, it is not known if red blood cell exchange can reduce the thrombo-inflammatory dynamic in sickle cell disease. The aim of this study is to evaluate the impact of red blood cell exchange on thrombo-inflammatory parameters in 20 adult sickle cell patients (10 patients on manual exchange and 10 patients on automatized exchange).

Full description

Prospective observational cohort with additional blood samples. This study is monocentric.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Sickled Cell Disease patient with SS or S/beta thalassemia genotype
Red blood cell exchange > 3 months
Up-to-date social security coverage
Patient able to understand the purpose and constraints of the research project
Patient has read the study information leaflet and does not object to the research.

Exclusion criteria

Thrombopenia < 50 G/L
Non-steroidal anti-inflammatory drugs < 7 days before enrolment
Anti-platelet agents < 7 days before enrolment
Pregnancy or breastfeeding
Patient objects to take part in the study
Patient under guardianship, curatorship or safeguard of justice
Patients with ongoing clinical trial requiring collection of additional blood samples