Evaluation of the Incidence of NTRK Gene Fusion in Adult Brain Tumours (NTRK Fusion)

GCS Ramsay Santé pour l'Enseignement et la Recherche

Status

Completed

Conditions

Glioma

Treatments

Other: Glioma data collection

Other: Brain metastasis data collection

Study type

Observational

Funder types

Other

Identifiers

NCT05025969

COS-RGDS-2020-06-072

Details and patient eligibility

About

This is a retrospective, mono centric, exploratory study to assess the incidence of a genomic alteration: NTRK gene fusion, in adult gliomas and brain metastases.

Full description

Retrospective mono centric study of medical data (clinical, histological, molecular and imaging) from medical records and analysis of available excisional tissue samples.

Enrollment

140 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult male or female subject;
Glioma or brain metastasis operated on in our institution, histologically confirmed (WHO classification 2016);
Subject with a frozen tumour sample < 5 years old;
Subject for whom all clinico-radiological data are available;
Subject affiliated to a health insurance scheme;
Subject who has been informed of the research and who has not indicated his opposition to the use of his medical data and who has signed a consent for the use of his tumour sample.

Exclusion criteria

Patient under legal protection, guardianship or deprived of liberty by judicial or administrative decision
Biological samples not available and/or in insufficient quantity for analysis