Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis (PRFperio)

Medical University of Bialystok

Status

Active, not recruiting

Conditions

Periodontitis

Periodontal Disease

Treatments

Biological: SRP+iPRF

Procedure: SRP

Study type

Interventional

Funder types

Other

Identifiers

NCT06920849

APK.002.122.2022 (Other Identifier)

UniBial

Details and patient eligibility

About

Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.

Full description

Forty subjects diagnosed with periodontitis were randomly divided into two groups. In the test group, SRP was performed with the subsequent application of iPRF into periodontal pockets, while in the control group SRP was performed alone. Clinical examination was performed before and 1, 3 and 6 months after treatment. For inflammation mediators levels determination in GCF samples ELISA method will be used.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

clinical and radiological features of periodontitis in stage II, III or IV
presence of at least 4 teeth and at least 2 pockets (localized not on the same tooth) with a depth of at least 5 mm in each quadrant

Exclusion criteria

periodontal treatment within 3 months prior to the study;
antibiotic therapy within 3 months prior to the study;
smoking; presence of systemic diseases affecting periodontal healing, i.e.: immunosuppressive diseases, diabetes, osteoporosis, AIDS, hypertension treated with calcium channel blockers;
use of steroids or other immunosuppressive drugs;
coagulation disorders and use of drugs affecting its mechanisms;
pregnant and breastfeeding women