Evaluation of the Ketogenic Potential of Different Diet Supplements

Université de Sherbrooke

Status

Completed

Conditions

Healthy Adults

Treatments

Dietary Supplement: Octanoate -

Dietary Supplement: Carnitine

Dietary Supplement: Butyrate -

Dietary Supplement: Octanoate +

Dietary Supplement: Leucine

Dietary Supplement: Control

Dietary Supplement: Butter fraction

Dietary Supplement: Butyrate +

Study type

Interventional

Funder types

Other

Identifiers

NCT02693106

2014-387

Details and patient eligibility

About

Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.

Full description

The aim of this study is to evaluate the capacity of different dietary supplements to increase ketone production in healthy adults. Each supplement (leucine, butyrate, octanoate, carnitine or butter fraction rich in MCT) is evaluated for a period of 4-hour during which multiple blood samples are taken in order to measure ketone production.

Enrollment

13 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy adults aged of 18 years old or older.
Non-smoking.

Exclusion criteria

Diabetes or prediabetes
Uncontrolled hypertension
Uncontrolled thyroid function
Taking medication that will affect lipid/glucose metabolism
Severe infection or inflammation
Pregnancy

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

13 participants in 1 patient group

Ketogenic potential

Experimental group

Description:

Each participant has to go through a total of 8 visits, each visit corresponding to a standardize breakfast taken alone (control visit) or with one of the dietary supplements evaluated followed by a period of 4-hour with multiple blood sampling. Intervention 1: Control; no supplement Intervention 2: 5 g of leucine Intervention 3: 3.6 g of butyrate Intervention 4: 7.2 g of butyrate Intervention 5: 5 g of octanoate Intervention 6: 10 g of octanoate Intervention 7: 1.95 g of carnitine Intervention 8: 65 g of butter fraction rich in MCT

Treatment: