Status and phase
Conditions
Treatments
About
The purpose of this study is to determine the safety and tolerability of PA-824 when given with a single dose of midazolam, and to determine whether PA-824 inhibits CYP3A to a clinically important degree as measured by the effect of PA-824 on the pharmacokinetics of midazolam, a known CYP3A substrate.
Full description
This study is an open-label, fixed sequence design. 14 subjects will receive a single dose of 2 mg midazolam, followed by a 2-day wash-out. Following the wash-out, all subjects will receive PA-824 once daily for 14 days. All patients will receive a single dose of 2 mg midazolam on the 14th day of PA-824 dosing. This study will evaluate 400 mg PA-824.
Enrollment
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Volunteers
Inclusion criteria
Exclusion criteria
Medical History
Any clinically significant (as deemed by the Principal Investigator) history, acute illness (resolved within 4 weeks of screening), or presence of cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal (including eating disorders), endocrine, metabolic, immunologic, dermatologic, neurologic, psychological, or psychiatric disease.
History of peptic ulcer disease, gastritis, esophagitis, or gastroesophageal reflux disease.
History of any clinically significant cardiac abnormality (as deemed by the Principal Investigator).
Any clinically significant ECG abnormality at Screening (as deemed by the Principal Investigator and the Sponsor's Medical Monitor)
Note: the following can be considered not clinically significant without consulting Sponsor's Medical Monitor:
History of prolonged QT interval.
Family history of Long-QT Syndrome or sudden death without a preceding diagnosis of a condition that could be causative of sudden death (such as known coronary artery disease or CHF or terminal cancer)
Resting pulse rate < 40 or > 100 bpm at Screening.
At Screening blood pressure greater than 140/90 mm Hg or below 95/65 mm Hg (supine, after a minimum 5-minute supine rest)
At either Screening or the pre-dose read before the first dose, a QTcB (Bazett's correction) >450ms for men and women, calculated from the average of triplicate reads collected at the screening and predose sitting.
At either Screening or the pre-dose read before the first dose, a QTcF (Fridericia's correction) >450ms for men and women, calculated from the average of triplicate reads collected at the screening and predose sitting.
History of hypokalemia or hypomagnesemia.
History or presence of alcoholism or drug abuse within the past 2 years (as deemed by the Principal Investigator).
Use of alcohol within 72 hours prior to dosing.
Significant history of drug and/or food allergies (as deemed by the Principal Investigator).
For women, subject is pregnant (positive test for serum HCG at Screening or Check-in), breastfeeding or planning to conceive a child within 30 days of cessation of treatment.
For males, planning to father a child within 12 weeks of cessation of treatment.
History of lens opacity or evidence of lens opacity on slit lamp ophthalmologic examination.
Specific Treatments
Any contraindication to the use of nitroimidazoles, or prior treatment with PA-824 or OPC-67683.
Use of any systemic or topical prescription medication within 14 days prior to dosing or during the study, except hormonal contraceptives in women.
Use of any systemic or over-the-counter medication including vitamins, herbal preparations, antacids, cough and cold remedies, etc., within 7 days prior to dosing or during the study treatment periods.
Use of any drugs or substances within 30 days prior to dosing, known to be strong inhibitors or inducers of cytochrome P450 enzymes (including quinidine, tyramine, ketoconazole, testosterone, quinine, gestodene, metyrapone, phenelzine, doxorubicin, troleandomycin, cyclobenzaprine, erythromycin, cocaine, furafylline, cimetidine, dextromethorphan, etc.) or known to prolong the QT interval (including amiodarone, bepridil chloroquine, chlorpromazine, cisapride, clarithromycin, disopyramide dofetilide, domperidone, droperidol, erythromycin, halofantrine, haloperidol, ibutilide, levomethadyl, mesoridazine, methadone, pentamidine, pimozide, procainamide, quinidine, quinolones, sotalol, sparfloxacin, thioridazine,) or barbiturates, opiates, or phenothiazines.
Use of any therapeutic agents known to alter any major organ function (e.g., barbiturates, opiates, phenothiazines, cimetidine, etc.) within 30 days prior to dosing.
Consumption of products containing grapefruit within 10 days prior to dosing.
Any special dietary changes during the 30 days prior to dosing, as deemed by the Principal Investigator in consultation with the Sponsor Medical Monitor.
Any strenuous exercise within 7 days of Check-in, as deemed by the Principal Investigator in consultation with the Sponsor Medical Monitor.
Donation of whole blood or significant loss of blood within 56 days prior to dosing.
Plasma donation within 7 days prior to dosing.
Participation in another interventional clinical trial within 30 days prior to dosing.
Based on Lab Abnormalities
Any serum creatinine or BUN measure beyond the upper limit of the normal range at Screening or Check-in. Individual values may be discussed with the Sponsor Medical Monitor.
Hemoglobin < 12.0 g/dL at the screening visit.
Positive Screening test for HCV, HBV, or HIV.
Any other factor which suggests to the Principal Investigator that the subject should not participate in the study.
Primary purpose
Allocation
Interventional model
Masking
14 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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