Evaluation of the Relationship Between Muscle Architecture and Muscle Strength in Female Gonarthrosis Patients

Bezmialem Vakif University

Status: Completed

Conditions: Osteoarthritis; Gonarthrosis; Osteo Arthritis Knee

Study type: Observational

Funder types: Other

Identifiers

NCT06003413

2020/162

Details and patient eligibility

About

The goal of this cross-sectional study is to evaluate muscle architecture changes and it's effect on muscle strength in female patients with gonarthrosis.Main questions are:

• Is there any correlation between muscle strength and muscle thickness, pennation angle fiber length?
• Is there any muscle architecture difference in gonarthrosis and is it effecting the muscle strength? The investigators will enroll patients with unilateral gonarthrosis so that investigators can compare the changes within osteoarthritic and healthy knee with the same physical activity levels.

Full description

Knee osteoarthritis (OA) is a chronic disease characterized by morning stiffness, reduced joint range of motion, chronic pain, and decreased muscle strength, leading to functional limitations as the disease progresses . In patients with knee osteoarthritis, all muscles of the hip, knee, and ankle are affected in some way . Evidence suggests that impairments in muscle strength in the lower extremities contribute to increased pain and joint space narrowing. Voluntary muscle contractions lead to various changes in muscle architecture, including changes in fascicle angle and pennation angle as well as muscle thickness. While muscle cross-sectional area and thickness are primarily associated with the magnitude of generated force, parameters such as pennation angle have been found to be more related to explosive force. Ultrasonography (US) is a non-invasive imaging method that can visualize these changes. Muscle architecture parameters obtained from US can provide reliable data related to muscle contractility independently of surrounding muscles. Furthermore, US is considered to have similar validity to MRI imaging, which is the gold standard for displaying muscle architecture. Additionally, isometric muscle strength can be reliably measured using handheld dynamometers. Although studies have investigated the relationship between muscle strength and muscle architecture determined by US in patients with knee OA, these studies have predominantly examined the relationship in the quadriceps muscle, and muscles associated with the ankle have not been studied extensively.

Enrollment: 30 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• To be ≥18 years of age,
• Presence of unilateral knee OA (according to American College of Rheumatology criteria),
• Presence of knee OA with Kellgren/Lawrence (K/L) stage ≥2,
• Ability to live independently,
• Ability to walk without assistive devices.

Exclusion criteria

• History of surgery on the spine or lower extremities,
• History of inflammatory rheumatic disease,
• Severe cardiovascular disease,
• Neuromuscular disease affecting muscle strength,
• Individuals following a regular exercise program,
• Secondary osteoarthritis.

Trial design

30 participants in 2 patient groups

Osteoarthritic Knee

Description:

* Knees with Kellgren-Lawrence Stage 2-4 will admitted to this group * Vastus Lateralis, Tibialis Anterior, Lateral Gastrocnemius and Medial Gastrocnemius ultrasonography will be performed to evaluate muscle thickness, pennation angle and fascicle length. * Outcome Measures in Rheumatology (OMERACT) Ultrasound scores for knee will be evaluated * Isometric knee extension, isometric ankle dorsiflexion and isometric ankle plantar flexion strength will be evaluated with hand held dynamometer

Healthy Knee

Description:

* Healthy knees will be admitted to this group * Vastus Lateralis, Tibialis Anterior, Lateral Gastrocnemius and Medial Gastrocnemius ultrasonography will be performed to evaluate muscle thickness, pennation angle and fascicle length. * Isometric knee extension, isometric ankle dorsiflexion and isometric ankle plantar flexion strength will be evaluated with hand held dynamometer