Evaluation of the Relevance of Pharmacogenetics in the Prescription Off Antidepressants in a Military Population (PSYGEN)

Direction Centrale du Service de Santé des Armées

Status: Enrolling

Conditions: Ptsd; Depression; Anxiety

Treatments: Other: Cognitive test battery (optional); Biological: Blood collection; Other: Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT04987047

2021RC01

2021-A00809-32 (Other Identifier)

Details and patient eligibility

About

The treatment of depression, anxiety disorders and post-traumatic stress disorder (PTSD) is a main public health problem due to the frequency of these pathologies and the very partial effectiveness of the existent therapies. These illnesses generally require the prescription of several successive lines of antidepressant treatments before the treatments actually become effective, leading to a several week delay during which the patient suffers from the symptoms of his/her pathology and is also likely to experience the side effects of the treatment.

Pharmacogenetics is an individualized prescribing modality that aims to predict the most favorable treatment for a given individual based on the study of genetic variants of cytochromes.

The main hypothesis of this research is that the use of pharmacogenetics in routine practice in a population of military personnel requiring a first prescription of an antidepressant is of interest to improve the tolerance and effectiveness of the treatment.

Enrollment: 250 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Between 18 and 65 years-old;
• To benefit from a medical follow-up in the psychiatric department of an army training hospital;
• To present a pathology requiring an antidepressant treatment and whose prescription can wait 10 days;
• To have given written informed consent to participate in the study.

Exclusion criteria

• To be currently treated with an antidepressant or antidepressant stopped less than 15 days ago;
• To have one or more contraindication to the introduction of an antidepressant treatment;
• Pregnancy or breastfeeding;
• To require a measure of constraint.

Trial design

250 participants in 2 patient groups

Prescription with pharmacogenetics assistance

Description:

The participants randomized in this arm will received a prescription of antidepressants based on the results of pharmacogenetics analyses.

Treatment:

Other: Questionnaires

Other: Cognitive test battery (optional)

Biological: Blood collection

Prescription without pharmacogenetics assistance

Description:

The participants randomized in this arm will received a prescription of antidepressants left to the discretion of the clinician without pharmacogenetics assistance.

Treatment:

Other: Questionnaires

Other: Cognitive test battery (optional)

Biological: Blood collection