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The purpose of this study is to compare the procedures for the collection PMN cells on Terumo BCT's Spectra Optia® and COBE® Spectra Apheresis Systems.
Full description
The purpose of this study is to compare the procedures for the collection of granulocyte/ polymorphonuclear (PMN) cells on Terumo BCT's Spectra Optia® and COBE® Spectra Apheresis Systems and to establish the non-inferiority of the Spectra Optia Apheresis System with respect to the primary study endpoint, granulocyte/PMN cell collection efficiency.
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Inclusion criteria
Acceptable health status and vital signs per the AABB blood donation guidelines to permit blood donation, including:
Able to read, understand, and sign an English informed consent form.
Age ≥ 18 years.
Weight ≥ 50kg and < 227kg.
Male or non-pregnant, non-nursing female (a negative serum pregnancy test at screening and a negative urine pregnancy test prior to each mobilization).
Acceptable screening laboratory test results prior to the first PMN cell mobilization, including:
Adequate dual peripheral venous access to allow collection of granulocytes (PMN cells) and return of remaining cells, platelets and plasma.
If male, willing to use a condom during sexual relations with a female partner of child bearing potential until 48 hours following each G-CSF injection.
If female, willing to use a medically-acceptable contraceptive until 48 hours following each G-CSF injection.
Exclusion criteria
Positive screening for any of the following: HIV, HBV (except isolated HB core Ab reactivity), HCV, HTLV, Syphilis or West Nile Virus.
Currently pregnant or breast-feeding.
Collection or loss of specific volumes of whole blood or blood components during specified timeframes:
History of congestive heart failure.
History of uncontrolled hypertension (SBP/DBP >200/120 mmHg).
History or suspicion of active, peptic ulcer disease.
History of diabetes mellitus.
History of hematologic malignancy or chronic hematologic disorder.
Family history (parents, siblings, children) of hematologic malignancy.
History of deep vein thrombosis or venous thromboembolism, or bleeding disorder.
History of sickle cell disease or a positive SickleDex screen.
History of iritis or episcleritis.
History of autoimmune condition or disorder, unless approved by principal investigator.
Presence of psychological traits, or physiological or medical conditions that, in the opinion of the investigator, would make the subject unlikely to tolerate the procedures or complete the study.
History of use/anticipated need for lithium.
Received a G-CSF injection in the prior 4 months.
Known hypersensitivity to ethylene oxide.
Known hypersensitivity to G-CSF or hypersensitivity to any E. coli-derived products.
Known hypersensitivity to HES or corn.
Concurrent participation in another clinical trial or participation in a clinical trial within the past 30 days.
Subject is being treated with calcium channel blockers and/or antiepileptic medications. Note: This applies only to Subjects at Bonfils Blood Center whose collected product will undergo neutrophil function testing.
42 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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