Evaluation of the Survival of Inflamed Mature Single Rooted Teeth

Cairo University (CU)

Status: Unknown

Conditions: Regeneration

Treatments: Procedure: PRF; Procedure: Conventional

Study type: Interventional

Funder types: Other

Identifiers

NCT03725514

ENDO28

Details and patient eligibility

About

The majority of articles present in literature concerning the enrollment of tissue engineering in the field of root canal treatment is concerned with the treatment of affected teeth with immature apex, after proper systematic search online, only 4 articles where found that are dealing with the treatment of teeth with mature apex. These 4 studies are case reports. None of these studies has been a randomized clinical trial, the gold standard of interventional trials resulting in the highest level of evidence that contributes effectively in the clinical decision-making process as to the best intervention for the patient's condition providing the most effective clinical outcomes for the satisfaction of the patient. Since that the triad of regenerative endodontics are the key of success of any attempt to regenerate pulp, 2 different maneuvers shall be done in this study.

Full description

Preservation of the natural dentition had always been a primary objective in endodontic practice. When the pulp is diseased or requires removal for restorative reasons, it is replaced with an artificial filling material during conventional root canal treatment. Root canal treatment has lots of drawbacks, starting with different iatrogenic errors during endodontic procedures, weakening of remaining tooth structure which might affect the tooth survival. Also Root canal treated teeth require the placement of a post and core, which itself is doubtful whether it increases fracture resistance of the tooth or it weakens it. The most important drawback is that the survival of affected pulp is hindered by the conventional root canal treatment. Thus a new treatment approach was introduced utilizing the body ability to regenerate, called Pulp Regeneration. Regeneration was first introduced in the dental field as a solution for immature apex treatment, due to difficulties encountered during its conventional root canal treatment. Here the Pulp regeneration shall be used on vital mature teeth to increase the survival rate of the affected teeth.

Enrollment: 40 estimated patients

Sex: All

Ages: 16 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who are free from any physical or mental handicapping condition with no underlying systemic diseases.
• Non-pregnant females
• Single canalled teeth.
• Patients having vital, mature, single rooted teeth, clinical evidence of pulpitis and apical periodontitis.
• Positive patient/Guardian compliance for participation in the study.

Exclusion criteria

• Any known sensitivity or adverse reactions to medicaments or pharmaceuticals necessary to complete the trial.
• Non-restorable coronal portion of teeth involved in the trial.
• Non Vital teeth
• Immature teeth
• Traumatized teeth
• Radiographic evidence of external or internal root resorption.
• Single Rooted teeth with multiple canals.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

conventional

Active Comparator group

Description:

Conventional blood clot technique

Treatment:

Procedure: Conventional

PRF

Experimental group

Description:

Platelet Rich Fibrin Technique

Treatment:

Procedure: PRF