Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma

State University of New York - Downstate Medical Center

Status and phase: Completed; Phase 2

Conditions: Asthma

Treatments: Drug: Placebos; Drug: minocycline

Study type: Interventional

Funder types: Other

Identifiers

NCT00456677

Heikki31

Details and patient eligibility

About

Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.

Full description

This is a double-blind, placebo-controlled crossover study of adult asthmatics given minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are recorded. A standardized asthma quality of life symptoms assessment is made every four weeks (AQLQ, Juniper).

Enrollment: 20 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult asthmatics
• History of or current use of oral steroids to control symptoms

Exclusion criteria

• Pregnant women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

20 participants in 2 patient groups, including a placebo group

Minocycline

Experimental group

Description:

Addition of minocycline 150 mg po twice daily to current asthma treatment regimen.

Treatment:

Drug: minocycline

Placebos

Placebo Comparator group

Description:

Addition of placebo capsules po twice daily to current asthma treatment regimen

Treatment:

Drug: Placebos