Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness

Hospital Nord

Status

Enrolling

Conditions

Fluid Responsiveness Predictability

Fluid Resuscitation

Treatments

Drug: Fluid bolus administration

Study type

Observational

Funder types

Other

Identifiers

NCT07202637

ITV-VD

2023-A02636-39 (Other Identifier)

Details and patient eligibility

About

Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.

Enrollment

205 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.
Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.
Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.

Exclusion criteria

Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) < 30%.
Severe right ventricular dysfunction defined by TAPSE < 12 mm.
Cardiac arrhythmia or atrial fibrillation.
Abdominal compartment syndrome.
Amputation of one or both lower limbs.
Intracranial hypertension.
Pregnant women (ruled out by systematic pregnancy test at ICU admission).
Minors.