Evaluation of Thiol Disulfide Balance in Stage 1 Endometrium Cancer

Muğla Sıtkı Koçman University

Status: Completed

Conditions: Endometrium Cancer; Oxidative Stress

Treatments: Diagnostic Test: Disulphide(μmol/L); Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)

Study type: Observational

Funder types: Other

Identifiers

NCT04175067

09/08/2018-13-9

Details and patient eligibility

About

The purpose of this study is to investigate thiol-disulfide balance in early stage endometrium cancer patients.

Full description

To date various oxidative stress paramaters were studied in patients with endometrial cancer, however dynamic thiol disulfide hemostasis has not been previously investigated.

The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel & Neselioglu(1).

References

1- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/j.clinbiochem.2014.09.026.

Enrollment: 117 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Histopathologically confirmed diagnosis of stage I endometrium cancer

Exclusion criteria

• pulmonary disease
• pulmonary hypertension
• cardiac dysfunction
• renal dysfunction
• liver disease
• chronic ishemia
• systemic inflammation
• concomitant malignancy
• patients who use vitamin A,C or E (antioxidant vitamins)
• patients who use smoke
• patients who use drink alcohol
• patients who use addictive for any drug

Trial design

117 participants in 2 patient groups

Endometrium cancer

Description:

stage I endometrium cancer n=57

Treatment:

Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)

Diagnostic Test: Disulphide(μmol/L)

Healthy controls

Description:

Healthy volunteers n=60

Treatment:

Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)

Diagnostic Test: Disulphide(μmol/L)