Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus

Cairo University (CU)

Status and phase: Unknown; Phase 1

Conditions: Oral Lichen Planus

Treatments: Drug: topical chamomile

Study type: Interventional

Funder types: Other

Identifiers

NCT03793634

chamomile in OLP

Details and patient eligibility

About

Using of herbal medications as topical chamomile which has antioxidant, anti-inflammatory and anticarcinogenesis effect with little side effects is the aim for the future treatment of OLP.

Full description

Oral lichen planus (OLP) is a chronic inflammatory T cell mediated autoimmune disease that affects skin and any mucous membrane particularly oral mucosa.The patient complains of burning sensation, pain; interference with eating, swallowing and speech leading to worsening of quality of life.Oxidative stress plays a role in pathomechanism of OLP disease. Enzymatic and non- enzymatic anti-oxidants act as a physiological guard against reactive oxygen species (ROS) and cytokine-mediated toxicity.Herbal treatment is the aim of the future therapy.Chamomile has anti-oxidant , anti-inflammatory effect and accelerate healing.

Enrollment: 37 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Symptomatic OLP.
• Patients with no history of taking corticosteroids for the last 6 months.
• Patients who agree to take medication.
• Medically free

Exclusion criteria

• Patients with oral lesions other than OLP.
• Lichenoid reaction .
• Pregnant females and lactation.
• Smokers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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37 participants in 2 patient groups

topical chamomile

Experimental group

Description:

herbal medication which has antioxidant, anti-inflammatory and anticarcinogenesis effect.

Treatment:

Drug: topical chamomile

Topical Triamcinolone Acetonide

Active Comparator group

Description:

topical triamcinolone acetonide is the gold standard treatment of oral lichen planus.

Treatment:

Drug: topical chamomile