Evaluation of Tp-e Interval and Tp-e/QT Ratio in Dermatomyositis and Analysis of Their Relationship With Inflammation

The Third People's Hospital of Hangzhou

Status: Completed

Conditions: Dermatomyositis; Inflammation; Myocardial Repolarization

Treatments: Other: disease

Study type: Observational

Funder types: Other

Identifiers

NCT06002750

2021KA048

Details and patient eligibility

About

The goal of this observational study is to investigate ventricular repolarization utilizing Tp-e intervals and Tp-e/QT ratios in patients with DM. The main questions it aims to answer are:

• 1.Exploring the changes in ventricular repolarization parameters (QT interval, QTc interval, QTd, Tp-e interval, Tp-e/QT ratio) in patients with dermatomyositis, providing quantifiable indicators for early detection of arrhythmia in dermatomyositis patients;
• 2.Exploring the role of inflammation in ventricular repolarization in DM patients, providing a basis for in-depth research on the diagnosis and prevention of arrhythmia in DM patients.

Enrollment: 100 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Regardless of gender, registered residence and education level, voluntarily participate in this study and sign the informed consent form.

Clinical diagnosis of Dermatomyositis.

Exclusion criteria

Previous history of heart disease (such as myocardial infarction, cardiac pacing, congenital heart disease, ischemic heart disease, etc.), chronic kidney disease, etc; Patients with other connective tissue diseases; Pregnant and lactating women.

Taking drugs that affect electrocardiogram indicators, such as macrolides, quinolones, quinidine, amiodarone, antipsychotic drugs, etc.

Patients with severe lack of case data.

Trial design

100 participants in 2 patient groups

Dermatomyositis patients

Treatment:

Other: disease

The control group was comprised of age- and gender-matched healthy volunteers