Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia (infertility)

Ain Shams University

Status and phase: Enrolling; Early Phase 1

Conditions: Infertility Unexplained; Oligospermia

Treatments: Drug: co enzyme Q10 , L- Carnitine

Study type: Interventional

Funder types: Other

Identifiers

NCT06342856

idiopathic infertility

Details and patient eligibility

About

Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia

Full description

Evaluation of treatment with Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile men with Idiopathic Oligoasthenoteratospermia a placebo controlled clinical trial

Enrollment: 120 estimated patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

• of in¬fertility of 1 year or more without the use of contraception

Exclusion criteria

• o Active genital infections.

  • Patients with ejaculatory dysfunction
  • Azoospermia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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120 participants in 4 patient groups, including a placebo group

Group 1

Active Comparator group

Description:

will receive a daily dose of 200 mg of CoQ10 for 3 months

Treatment:

Drug: co enzyme Q10 , L- Carnitine

Group 2

Active Comparator group

Description:

will receive L-carnitine 1 tablet per day orally for 3 months

Treatment:

Drug: co enzyme Q10 , L- Carnitine

Group 3

Active Comparator group

Description:

will receive combination of a daily dose of 200 mg of CoQ10 and 1 tablet of L-carnitine for 3 months

Treatment:

Drug: co enzyme Q10 , L- Carnitine

Group 4

Placebo Comparator group

Description:

will receive a placebo for 3 months

Treatment:

Drug: co enzyme Q10 , L- Carnitine