Evaluation of Two Pharmacological Protocols for Pre-emptive Analgesia in Impacted Third Molar Surgery

F

Federal University of the Valleys of Jequitinhonha and Mucuri

Status

Completed

Conditions

Edema
Trismus
Pain

Treatments

Drug: Dexamethasone
Drug: Diclofenac Sodium associated with Codeine

Study type

Interventional

Funder types

Other

Identifiers

NCT02665533
1.354.720

Details and patient eligibility

About

The main aim of the study is to investigate the pre-emptive effect of dexamethasone and diclofenac associated to codeine to prevent the pain, edema and limited mouth opening at the extraction of third molar.

Full description

The surgery of third molar is usually associated with important post-surgical sequelae. The damage caused to tissue and bone may result in considerable pain, edema and trismus. The symptoms start gradually, peaking in 2 days after the extraction. The use of medications such as dexamethasone and diclofenac associated to codeine may support the prevention of post-surgical pain. This clinical trial aim compare the the pre-emptive effect of dexamethasone and diclofenac associated to codeine to prevent the pain, edema and limited mouth opening at the extraction of third molar.

Enrollment

18 patients

Sex

All

Ages

18 to 35 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with indication of asymptomatic bilateral extractions of lower third molars;
  • Aged 18 years or older;
  • Have a good health and no disease;

Exclusion criteria

  • Patients with history of any medication treatment within 15 days before the beginning of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

18 participants in 2 patient groups

Dexamethasone
Active Comparator group
Description:
Dexamethasone 8 mg, one capsule single preoperative dose.
Treatment:
Drug: Dexamethasone
Diclofenac Sodium associated with Codeine
Experimental group
Description:
Diclofenac Sodium 50 mg associated with Codeine 50 mg, one capsule single preoperative dose.
Treatment:
Drug: Diclofenac Sodium associated with Codeine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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