Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury

Boston Children's Hospital

Status: Enrolling

Conditions: Acute Kidney Injury

Treatments: Other: Discarded urine sample

Study type: Observational

Funder types: Other

Identifiers

NCT03263325

IRB-P00025852

Details and patient eligibility

About

Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes.

A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury.

This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.

Enrollment: 250 estimated patients

Sex: All

Ages: Under 8 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• less than or equal to 8 years of age
• scheduled for cardiac surgery

Exclusion criteria

• severe pre-existing renal insufficiency

Trial design

250 participants in 2 patient groups

AKI Group

Description:

Patients developing AKI after surgery

Treatment:

Other: Discarded urine sample

No AKI Group

Description:

Patients who do not develop AKI after surgery

Treatment:

Other: Discarded urine sample