Evaluation of V/Q Mismatch as Predictor of Pulmonary Postoperative Complications in Patients Undergoing Major Surgery (VQppc)

Università degli Studi di Ferrara

Status: Completed

Conditions: Postoperative Complications; Mechanical Ventilation Complication; Anesthesia

Treatments: Device: Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)

Study type: Observational

Funder types: Other

Identifiers

NCT05454917

VQppc

Details and patient eligibility

About

Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality. Little is known about the effect of intraoperative VQ mismatch on the occurrence of PPC. In this trial the investigators will evaluate if intraoperative VQ mismatch may predict PPC in a population of patients undergoing major surgery.

Full description

Pulmonary postoperative complications (PPC) are among the main causes of surgical complications affecting both postoperative morbidity and mortality. Little is known about the effect of intraoperative VQ mismatch on the occurrence of PPC.

PPC are classically considered associated to the occurrence of intraoperative atelectasis, and therefore to the development of a certain amount of shunt, but this concept have been recently questioned.

Recent studies showed indeed that, despite age is one of the main determinants of PPCs, increasing age is not associated to the increase of intraoperative shunt. Shunt therefore may not be the main determinant of PPC.

In this trial the investigators will evaluate if other causes of intraoperative VQ mismatch (e.g. low V/Q, high V/Q, dead space) may predict PPC in a population of patients undergoing major surgery.

Enrollment: 101 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-90 years
• Major elective surgery with general anesthesia
• Intraoperative cannulation of the radial artery for invasive pressure monitoring

Exclusion criteria

• Thoracic surgery with one lung ventilation
• Refuse to participate
• Emergency surgery

Trial design

101 participants in 1 patient group

Patients undergoing surgery

Description:

Mechanical measures, VQ mismatch evaluation

Treatment:

Device: Measure of ventilation/perfusion (V/Q) mismatch using Beacon ALPE (Automatic Lung Paramether Estimator)