Evaluation of Ventilatory Strategies During Laparoscopic Surgery

Maria Vittoria Hospital

Status: Completed

Conditions: Pneumonia

Treatments: Procedure: Patients ventilated with Positive End Expiratory Pressure plus Recruitment maneuver; Procedure: Patients ventilated with Positive End Expiratory Pressure; Procedure: First arm: patients ventilated with zero end expiratory pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT01923038

BCB232

MariaVittoria Hospital (Other Identifier)

Details and patient eligibility

About

Atelectasis involving declive areas often occurs during general anesthesia and may persist postoperatively. This phenomenon could be amplified by pneumoperitoneum and Trendelenburg position. Hypothesis: To evaluate whether the shape of the airway pressure-time curve, Stress Index (SI), during constant flow inflation can lead ventilator setting during general anesthesia.

Enrollment: 45 patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society Anesthesiology (ASA) I, II;
• age > 18 years;
• elective surgery

Exclusion criteria

• ASA III, IV;
• Age < 18 years;
• emergency surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

Patients ventilated with zero end expiratory pressure (ZEEP)

Active Comparator group

Description:

patients undergoing gynecologic laparoscopic surgery ventilated at zero end expiratory pressure

Treatment:

Procedure: First arm: patients ventilated with zero end expiratory pressure

Patients ventilated with positive end expiratory pressure

Active Comparator group

Description:

patients undergoing gynecologic laparoscopic surgery ventilated at PEEP

Treatment:

Procedure: Patients ventilated with Positive End Expiratory Pressure

recruitment plus PEEP

Active Comparator group

Description:

patients undergoing gynecologic laparoscopic surgery undergoing recruitment plus PEEP

Treatment:

Procedure: Patients ventilated with Positive End Expiratory Pressure plus Recruitment maneuver