Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction

Zahra Nejati

Status and phase: Not yet enrolling; Phase 4

Conditions: Temporomandibular Joint Disorders; Dry Socket; Coenzyme Q10; Molar, Third

Treatments: Drug: Placebo; Drug: Coenzyme Q10 100 MG Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT06452134

IR.MUK.REC.1403.030

Details and patient eligibility

About

The goal of this clinical trial is to asses the effect of Coenzyme Q10 administration in patients from any gender group who are older than 18 years old undergoing wisdom tooth extraction. The main questions it aims to answer are:

does Coenzyme Q10 help with better tissue healing? does Coenzyme Q10 administration lower the prevalence of Dry socket after surgery? does Coenzyme Q10 prevent TMD (Temporomandibular disorders) while recovering from surgery? how does Coenzyme Q10 administration effect the answers to SF-36 health survey in patients? Researchers will compare Coenzyme Q10 to a placebo (a look-alike substance that contains no drug) to see if it has any effect on mentioned parameters.

Participants will:

• take coenzyme Q10 (100mg) daily for 30 days after surgery.
• will be examined and evaluated 1, 7, 14 and 30 days after completion of surgery.

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years old that require mandibular or maxillary molar, third tooth extraction as Oral and Maxillofacial surgeon's clinical diagnosis.

Exclusion criteria

• The patient's departure from Sanandaj
• The patient's disagreement with the study protocol
• The Patient's demise
• The patient's hospitalization for unrelated illnesses
• The patient's discontent with the care they received
• The patient's failure to show up for follow-up appointments
• The patient's sensitivity to Coenzyme Q10

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

Intervention group

Experimental group

Description:

This arm of the study includes 35 of participants who will be given Coenzyme Q10 100 MG Oral Tablet for 30 days.

Treatment:

Drug: Coenzyme Q10 100 MG Oral Tablet

Control group

Placebo Comparator group

Description:

This arm of the study includes 35 of participants who will be given Placebo ( a look-alike substance ) with same tablet form given daily for a period of 30 days after surgery.

Treatment:

Drug: Placebo