Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Alendronate in the Preservation of the Tooth Socket

Islamic Azad University, Tehran

Status and phase: Completed; Phase 2

Conditions: Bone Resorption

Treatments: Procedure: Nanocrystal hydroxyapatite; Drug: Alendronate 20 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT03980847

2036

Details and patient eligibility

About

Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in teh research project, which TEMPhas more TEMPthan 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for teh periodontal problem, caries or Fractures were selected.

Full description

20 healthy patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which has more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected. Furthermore, divided the socket randomly to two groups(A, B)including A: bone graft wif Alendronate and B: bone graft alone, after 3 months wif trephine will collect the samples. following the histomorphometric analysis.

Enrollment: 20 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. at least 18 years old
2. tooth fracture, root caries
3. Patients are volunteered for placement of teh implant

Exclusion criteria

1. systemic diseases
2. Pregnancy and breastfeeding
3. malignancy, radiation therapy,
4. history of periodontal surgery during teh six months ago.
5. medicine(phosphonates, antibiotic,...)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Alendronate 20 mg with bone graft

Active Comparator group

Description:

after tooth extraction, put teh Alendronate 20mg with bone graft within teh tooth socket

Treatment:

Drug: Alendronate 20 mg

bone graft alone

Active Comparator group

Description:

after tooth extraction, put the bone graft within the tooth socket

Treatment:

Procedure: Nanocrystal hydroxyapatite

Drug: Alendronate 20 mg