Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Lovastatin in the Preservation of the Tooth Socket

Islamic Azad University, Tehran

Status and phase: Unknown; Phase 2

Conditions: Bone Loss

Treatments: Drug: Lovastatin 40 MG; Procedure: without drug with Bone graft

Study type: Interventional

Funder types: Other

Identifiers

NCT03981601

2038

Details and patient eligibility

About

Twenty patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which have more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected.

Full description

twenty healthy patients referring to periodontics department of Boroujerd Azad university of dentistry after obtaining consent to participate in the research project, which has more than 20 teeth, are over 18 years old and require socket preservation surgery to tooth extraction for the periodontal problem, caries or Fractures were selected. moreover, divided the socket randomly to two groups(A, B)including A: bone graft with lovastatin and B: bone graft alone, after 3 months with trephine will collect the samples. following the histomorphometric analysis.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. at least 18 years old
2. tooth fracture, root caries
3. Patients are volunteered for placement of the implant

Exclusion criteria

1. systemic diseases
2. Pregnancy and breastfeeding
3. malignancy, radiation therapy,
4. history of periodontal surgery during the six months ago.
5. medicine(phosphonates, antibiotic,...)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

lovastatin 40 mg with bone graft

Active Comparator group

Description:

after tooth extraction, put teh lovastatin40 mg wif bone graft wifin tooth socket

Treatment:

Drug: Lovastatin 40 MG

without drug with bone graft

Active Comparator group

Description:

after tooth extraction, put the bone graft wifin tooth socket

Treatment:

Procedure: without drug with Bone graft