Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage

Assiut University

Status and phase: Completed; Phase 4

Conditions: Missed Abortion

Treatments: Drug: Misoprostol 100Mcg Tab; Drug: Evening Primrose Oil 1000 MG

Study type: Interventional

Funder types: Other

Identifiers

NCT03584698

EPOM

Details and patient eligibility

About

Termination of pregnancy is an important subject that has complex and emotional controversies. The most common time of termination of pregnancy is the mid-trimester which has two-thirds of all serious abortion-related complications. There are many indications for mid trimester termination of pregnancy such as missed abortion, serious fetal abnormalities and lastly some women do not wish to continue a pregnancy and will often request termination of pregnancy

Enrollment: 144 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Nullipara or previous vaginal delivery only
• Bishop score was ≤ 5
• Women who will accept to participate in the study

Exclusion criteria

• Multiple gestations
• Rupture of fetal membranes
• Previous cesarean sections
• Women with heavy bleeding
• Evidence of low implanted placenta by US
• Evidence of intra-uterine infection (either clinical or laboratory)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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144 participants in 2 patient groups

study group

Experimental group

Description:

Misoprostol + Evening primrose oil group

Treatment:

Drug: Evening Primrose Oil 1000 MG

Drug: Misoprostol 100Mcg Tab

control group

Active Comparator group

Description:

Misoprostol only group

Treatment:

Drug: Misoprostol 100Mcg Tab