Everolimus Related Pneumonitis in MBC

Fudan University

Status: Completed

Conditions: Pneumonitis; Everolimus

Study type: Observational

Funder types: Other

Identifiers

NCT03730428

YOUNGBC-5

Details and patient eligibility

About

To study the drug-related pneumonitis during mTOR inhibitor therapy in patients with metastatic breast cancer.

Enrollment: 86 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Postmenopausal woman (or premenopausal women treated with LHRHa) diagnosed with HR+，HER2- metastatic breast cancer
2. Treated with everolimus for at least one month in metastatic setting
3. With baseline and at least one follow-up chest CT during everolimus therapy.
4. Complete medical history

Exclusion criteria

1. Incomplete medical history
2. Radiographic imaging unavailable

Trial design

86 participants in 2 patient groups

pneumonitis group

Description:

Patients who developed drug-related pneumonitis after treated with everolims

non-pneumonitis group

Description:

Patients who didn't develop drug-related pneumonitis after treated with everolims