EVLWI Exhibits Pulmonary and Systemic Permeability in Sepsis Related ALI/ARDS

Chang Gung Medical Foundation

Status: Unknown

Conditions: Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome

Treatments: Device: PiCCO monitoring system

Study type: Observational

Funder types: Other

Identifiers

NCT01694147

99-3957B

Details and patient eligibility

About

To investigate the possible mechanisms of pulmonary and systemic permeability change including cytokine, extravascular lung water index (EVLWI), and oxygenation parameters in patients with sepsis related acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).

Full description

This investigation is a prospective control study. Informed consents will be obtained from all patients or their surrogates prior to the procedure of EVLWI measurement and blood sampling for molecular measurement including cytokines.

From July 2011 to June 2014, consecutive septic patients with ARDS in intensive care units (ICUs) will be enrolled at Chang Gung Memorial Hospital, a university-affiliated hospital in Taiwan. EVLWI will be measured by PiCCO monitoring system. Serum cytokine such as endothelin-1, TNF-alfa, IL-6, Tie-1, Tie-2, angiopoietin-1, angiopoietin-2,VEGF and thrombomodulin will be measured.

Enrollment: 60 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• sepsis in ICU within 48 hours,
• mechanical ventilator use,
• PaO2/FiO2 < 300,

Exclusion criteria

• age younger than 20 years,
• known pregnancy,
• participation in another trial within 30 days before meeting the eligibility criteria, and
• terminal malignancy.

Trial design

60 participants in 1 patient group

patients with sepsis related ALI/ARDS.

Description:

Consecutive septic patients with ALI/ARDS in medical intensive care units (ICUs) will be enrolled. EVLWI will be measured by PiCCO monitoring system.

Treatment:

Device: PiCCO monitoring system