Evolution of DMDD Children and Adolescent (ACTIHUMEURp3)

Centre Hospitalier Universitaire, Amiens

Status: Enrolling

Conditions: Disruptive Mood Dysregulation Disorder; Suicidal Behaviors; Prognosis Factors; Actigraphy

Study type: Observational

Funder types: Other

Identifiers

NCT04820946

PI2020_843_0013

Details and patient eligibility

About

Little is known about the natural course and prognosis factors of inpatients and outpatients with Disruptive Mood Dysregulation Disorder (DMDD). The investigators conducted a cross-sectional study to determine the evolution of a sample of DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors. A group of patients with various episodic mood disturbances was used as a clinical case control group.

In addition to change in DMDD symptoms across time, the investigators examined the onset and persistence of psychiatric comorbidity using the KIDDIE-SADS PL and suicidal behaviors using the Colombia Suicidality Severity Rating Scale. The investigators also examined the persistence of depressive symptoms using the Beck Depression Inventory (BDI-II), the persistence of emotional lability (Affective Lability Scale-18), borderline traits (Abbreviated Diagnostic of Inventory Borderline). Socio-demographic, clinical features and actigraphy-measured sleep characteristics determined between 2013 and 2018 were used to predict the evolution of the DMDD patients and the clinical control group.

Enrollment: 55 estimated patients

Sex: All

Ages: 10 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Boys and girls between 10 and 25-year-old
• patients who had been referred to the university hospital of Amiens for suicidal behaviors between 2013 and 2018
• patients who participated to the study "Clinical and actigraphy-measured profiles of inpatient youths with suicidal behavior: exploration of the severe mood dysregulation"

Exclusion criteria

• No affiliation to a social security service
• Persons deprived of their liberty as stipulated in article L.1121-6 of the Public Health Code

Trial design

55 participants in 2 patient groups

various episodic mood disturbances patient group

Description:

A group of patients with various episodic mood disturbances was used as a clinical case control group.

Disruptive Mood Dysregulation Disorder (DMDD) patient group

Description:

DMDD patients referred to the hospital for suicidal behaviors between 2013 and 2018 in terms of diagnostic stability, psychiatric comorbidity, and psychosocial factors.