Evolution of Pulmonary Capillary Blood Volume (VcEP)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Pulmonary Embolism

Treatments: Other: diffusion NO/CO method

Study type: Observational

Funder types: Other

Identifiers

NCT00941187

0808076

2008-A01122-53 (Other Identifier)

Details and patient eligibility

About

The purpose of this monocentric, preliminary study is to assess the evolution of pulmonary capillary blood volume (Vc), measured by the double diffusion nitric oxide/carbon monoxide (NO/CO) method (Guenard et al.; Respir Physiol 1987), from the starting of the anticoagulant therapy to 6 months after, and to search correlations with the evolution of clinical (dyspnea and results of the 6 minutes walking test), biological (BNP; Troponin), echocardiographic (right ventricular dysfunction, pulmonary arterial pressure) and ventilation/perfusion lung scan data.

Enrollment: 50 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with a first episode of symptomatic pulmonary embolism, treated with anticoagulant
• Age from 18 to 75 years-old

Exclusion criteria

• Confirmed pulmonary embolism in the past
• Massive pulmonary embolism, thrombolytic treatment
• Confirmed left heart systolic dysfunction
• Confirmed asthma, chronic obstructive pulmonary disease or pulmonary fibrosis
• Expected life below 6 months
• Pleural effusion with indication of evacuation
• Bronchopulmonary cancer
• Pulmonary surgery with resection of two lobes minimum
• Predictable incapacity to complete the 6 minutes walking test

Trial design

50 participants in 1 patient group

patients after a first episode of pulmonary embolism

Treatment:

Other: diffusion NO/CO method