Evolution of the Lymphocyte Phenotype in Patients with Infection in Intensive Care Unit (REAPHEN)

Regional University Hospital Center (CHRU)

Status: Enrolling

Conditions: Patients with Abdominal Infection; Patients with Severe Polytrauma; Patients with Severe Neurological Lesion; Patients Undergoing Esophagectomy

Treatments: Procedure: Lymphocyte Phenotyping Procedure

Study type: Interventional

Funder types: Other

Identifiers

NCT06415474

29BRC23.0109

Details and patient eligibility

About

Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly prolonged infection. A study of their lymphocyte phenotype over time could help explore the phenomenon of immunoparalysis.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria:

• Postoperative esophagectomy surveillance within the last 24 hours.
• Patients with intra-abdominal infection
• Neurological patients with intubation planned for more than 24 hours (subarachnoid hemorrhage with coma, severe head trauma, ischemic or hemorrhagic stroke with coma).
• Polytrauma with intubation planned for more than 24 hours
• Patient aged 18 and over
• Patient with social security coverage

Non-inclusion criteria :

• Hereditary immune deficiency HIV-AIDS
• Malignant hemopathies
• Immunosuppressive treatment other than corticosteroid therapy or chemotherapy
• Patient under legal protection
• Pregnant or breast-feeding women

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

Phenotyping arm

Other group

Description:

There is only one arm in the study. All patients (i.e. our 4 target populations) will undergo the same phenotyping procedure.

Treatment:

Procedure: Lymphocyte Phenotyping Procedure