Ex Vivo Evaluation of the Interest of the Association of Platinum With a Molecule BH3-mimetic ABT-737 in Samples of Ovarian Tumors (ABT737 exvivo)

Centre Francois Baclesse

Status: Completed

Conditions: Ovarian Cancer

Treatments: Other: culture ex vivo with exposure to different therapeutic agents alone or in combination.

Study type: Observational

Funder types: Other

Identifiers

NCT01440504

ABT-737 ex vivo

Details and patient eligibility

About

The aim of the study is to quantify the ex vivo induction of apoptosis by ABT-737 + association platinum in samples exposed and demonstrate the value of this combination compared to the agents used alone.

Enrollment: 36 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient aged over 18 years
• Ovarian cancer patients with at least five tumor samples does not affect the diagnosis, based on other tumor masses
• Surgery of any initial chemotherapy naive
• Patient information and signed informed consent

Exclusion criteria

• A person deprived of liberty or under guardianship
• Insufficient tumor samples of ovarian cancer.