Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Apical Periodontitis

Kırıkkale University

Status: Completed

Conditions: Apical Periodontitis; Oxidative Stress

Study type: Observational

Funder types: Other

Identifiers

NCT07243353

2024/046

Details and patient eligibility

About

The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis. Samples were collected from patients who had undergone treatment with the Nd:YAG laser and compared with samples collected from patients who had not received this treatment. The study commenced with a sample of 60 patients. However, the study was completed with 58 patients. The study concluded with the following finding: the use of Nd:YAG lasers was not found to be superior.

Enrollment: 58 patients

Sex: All

Ages: 25 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged between 25 and 50 years and classified as American Society of Anesthesiologists (ASA) I. The maxillar and mandibular incisors and premolars with chronic apical periodontitis of a PAI score of 3 or 4 were included.

Exclusion criteria

• Patients with American Society of Anesthesiologists (ASA) classification II or higher, pregnant, patients with localised or generalised periodontitis, patients who had used antibiotics in the last month and anti-inflammatory drugs in the last week, smokers, and teeth with internal or external root resorption, swelling, palpation pain or fistula in the relevant area, root fracture or incomplete root formation, and teeth that could not be isolated with rubber dam were not included in the study.

Trial design

58 participants in 2 patient groups

Nd:YAG laser group

Description:

Group treated with Nd:YAG laser

Control group

Description:

Group not treated with Nd:YAG laser