Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis

Osaka City University

Status: Completed

Conditions: Femur Head Necrosis

Study type: Observational

Funder types: Other

Identifiers

NCT00244400

338

Details and patient eligibility

About

The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Full description

Femur head necrosis is one of the major side effects of corticosteroid therapy. Since corticosteroids are metabolized by hepatic cytochrome P-450 (CYP) 3A, a low endogenous activity of this enzyme may contribute to the pathogenesis of ONFH. The purpose of the present study was to examine the possible association of hepatic CYP3A activity and the susceptibility to femur head necrosis in patients treated with corticosteroids.

Sex: All

Ages: 14 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of avascular necrosis of the femur

Exclusion criteria

• Old age (> 70 years)
• Severe hepatic or renal dysfunction
• Heart disease
• Current use of known CYP3A-inducing or -inhibiting drugs
• Morbid obesity