Examining the Efficacy of tDCS in the Attenuation of Epileptic Paroxysmal Discharges and Clinical Seizures

Herzog Hospital

Status: Completed

Conditions: Ohtahara Syndrome

Treatments: Device: High-definition (HD) transcranial direct current stimulator, HD-tDCS with 4x1 HD adaptor

Study type: Interventional

Funder types: Other

Identifiers

NCT02960347

Meiron 2013-4

Details and patient eligibility

About

The current study examined the feasibility of High-Definition tDCS (HD-tDCS) in reducing epileptiform activity in a 30-month-old child suffering from early onset epileptic encephalopathy. HD-tDCS was administered over 10 intervention days spanning two weeks including pre- and post-intervention video-electroencephalography (EEG) monitoring.

Enrollment: 1 patient

Sex: Male

Ages: 10 to 36 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Initial diagnosis of Ohtahara syndrome/West syndrome/ Lennox-Gastaut syndrome by a pediatric neurologist using video-EEG
2. Ongoing synchronous Hypsarrhythmia
3. Modified Hypsarrhythmia with a consistent focus of paroxysmal discharges
4. Signed informed consent of parents/immediate legal guardian
5. Age 10 to 36 months
6. Infant should be in a steady state indicated by a baseline test of electrolytes and biochemistry blood test, heart rate, temperature, respiratory rate, and saturation.

Exclusion criteria

1. Metal in the cranium, skull defects, or skin lesions on scalp (cuts, abrasions, rash) at proposed electrode sites.
2. History of adverse reaction to neurostimulation
3. Significant ECG abnormality

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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1 participants in 1 patient group

Active tDCS

Experimental group

Description:

open label active tDCS treatment

Treatment:

Device: High-definition (HD) transcranial direct current stimulator, HD-tDCS with 4x1 HD adaptor