Examining the Impact of Blood Flow Restricted Aerobic Exercise on PGC-1α mRNA Expression in Young Healthy Males

Queen's University

Status: Completed

Conditions: Mitochondrial Biogenesis

Treatments: Other: CTL Exercise; Other: BFR Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03717948

BFRNP

402635 (Other Grant/Funding Number)

Details and patient eligibility

About

This crossover study investigates the effects of restricting arterial blood flow during cycling exercise on PGC-1α and its upstream signalling pathways. In a randomized order, participants will exercise once for 30 minutes with restricted blood flow and then will exercise once for 30 minutes with no blood flow restriction.

Enrollment: 13 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 3 hours of physical activity per week
• No previous cycling training
• No concurrent involvement in another training program
• Body mass index < 30 kg/m2

Exclusion criteria

• Presence of cardiovascular disease
• Presence of metabolic disease
• Taking regular oral medication
• Current smoker

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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13 participants in 2 patient groups

CTL - BFR

Experimental group

Description:

CTL Exercise then BFR Exercise

Treatment:

Other: BFR Exercise

Other: CTL Exercise

BFR - CTL

Experimental group

Description:

BFR Exercise then CTL Exercise

Treatment:

Other: BFR Exercise

Other: CTL Exercise