Examining the Long-Term Risks of Oophorectomy

Parker, William H., M.D.

Status: Completed

Conditions: Breast Cancer; Death; Stroke; Coronary Heart Disease; Hip Fracture; Cancer; Ovarian Cancer

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00655447

PARW-OVCONS-0307

Details and patient eligibility

About

At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.

Full description

We are conducting a prospective, observational study of 32,175 women participants of the Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are evaluating mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

Enrollment: 32,175 patients

Sex: Female

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women who had hysterectomies were classified into simple hysterectomy or hysterectomy with both ovaries removed.

Exclusion criteria

• Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip fracture before entering the study were excluded. Cancer as an indication for hysterectomy also excluded.
• Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of hysterectomy, or those who had oophorectomy before hysterectomy were excluded.

Trial design

32,175 participants in 2 patient groups

1

Description:

all women having a hysterectomy with oophorectomy

2

Description:

all women having a hysterectomy without removal of ovaries