Examining the Relationship Between Acute Meal Intake and Inflammation in Children

University of Illinois at Urbana-Champaign

Status: Completed

Conditions: Inflammation; Obesity

Treatments: Other: Eggs and Carbohydrates

Study type: Interventional

Funder types: Other

Identifiers

NCT03597542

17112

Details and patient eligibility

About

Recent evidence has shown that obese and overweight children exhibit states of chronic inflammation. In obese adults, a high carbohydrate meal induces an inflammatory response; however, the effects of a high carbohydrate meal on biomarkers of inflammation has not previously been examined in children. The purpose of this research project is to characterize the inflammatory response to a high carbohydrate versus a low carbohydrate meal in healthy weight, overweight, and obese children (age 7-17 years). After completing informed consent/assent, a Dual-energy X-ray Absorptiometry (DXA) scan, and baseline blood draw on experimental day 1, children will then return to the lab two times to ingest either a high or low carbohydrate beverage followed by post-meal blood collection for a total of 3 blood draws. Biomarkers of inflammation will be analyzed by flow cytometry and enzyme-linked immunosorbent assay (ELISA). Participants will be recruited through various studies through the Neurocognitive Kinesiology Lab/Body Composition and Nutritional Neuroscience Labs as well as through the local Champaign-Urbana community. Data from this project will provide a better understanding of the inflammatory response to different meals in healthy weight, overweight, and obese children.

Enrollment: 36 patients

Sex: All

Ages: 7 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the ages of 7-17

Exclusion criteria

• Younger than 7 years and older than 17 years
• Presence of allergies to eggs and/or sugar substitutes
• Presence of heart or respiratory disease
• Presence of uncontrolled hypertension, diabetes
• Use of anti-inflammatory medications
• Presence of cancer or metabolic disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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36 participants in 2 patient groups

Maltodextrin

Experimental group

Description:

Participants will consume 56g of maltodextrin dissolved in 500mL of water.

Treatment:

Other: Eggs and Carbohydrates

Egg

Experimental group

Description:

Participants will consume 36g of spray-dried egg powder (equivalent to 3 eggs) dissolved in 500mL of water.

Treatment:

Other: Eggs and Carbohydrates