Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women

Saint Thomas Hospital (HST)

Status: Enrolling

Conditions: Preeclampsia; Severe Preeclampsia

Treatments: Diagnostic Test: Arterial Blood gases

Study type: Interventional

Funder types: Other

Identifiers

NCT07265336

4558

Details and patient eligibility

About

The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.

This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.

The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.

Enrollment: 100 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Gestational age: 24-40 weeks
• Cases: Diagnosis of severe preeclampsia
• Control: Normal blood pressure

Exclusion criteria

• Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).
• Clinical conditions that could hinder the results (diarrhea, vomit)
• Recent use of bicarbonate

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Severe preeclampsia

Experimental group

Description:

Pregnant subjects with severe preeclampsia

Treatment:

Diagnostic Test: Arterial Blood gases

Normotensive

Experimental group

Description:

Pregnant subjects with normal blood pressure

Treatment:

Diagnostic Test: Arterial Blood gases