Exercise After Intensive Care Unit: a Randomised Controlled Trial (REVIVE)

Ulster University

Status and phase

Completed

Phase 2

Conditions

Critical Illness

Intensive Care

Treatments

Other: Exercise Programme

Other: Standard Care

Study type

Interventional

Funder types

Other

Identifiers

NCT01463579

11/0291

Details and patient eligibility

About

The purpose of this study is to test if a 6-week programme of exercise improves physical function and health related quality of life in patients following intensive care who are discharged from hospital. In this study the investigators will compare the physical function and health related quality of life of patients who attend the programme with patients who do not. The 6 week exercise programme will be run by physiotherapy staff, and will mostly take place in a hospital gym. The investigators will measure patients' physical function, exercise capacity, level of breathlessness and their quality of life before and after the 6-week programme, and 6 months later. The investigators will also interview patients to ask their views about the acceptability, enjoyment and satisfaction with the exercise programme. If this study shows that the physical function and health related quality of life are improved in those who took part in the exercise programme, then it will provide useful information which will help the development of services for patients after critical illness. The results will also provide information which will help us design future clinical trials for this patient population.

Full description

Most critically ill adult patients require ventilatory support during their intensive care unit stay. Following discharge home patients often still suffer from reduced physical function, exercise capacity, health related quality of life and social functioning for at least 2 years. There is usually no support to address these longer term problems specific to critical illness for patients after hospital discharge. Little research has been carried out into interventions which could improve physical function and quality of life, or enhance speed of recovery in these patients. While there is evidence to support the rehabilitation of critically ill patients within intensive care units, there is a paucity of literature to support rehabilitation following discharge from intensive care and hospital. Therefore, there is a clear and urgent need to investigate interventions which could improve the recovery of patients discharged home after intensive care. This is emerging as a prominent therapeutic objective for the future for this population.

This study will investigate whether a programme of exercise following discharge from hospital will improve outcome in patients following critical illness compared to standard care.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age ≥ 18 years
ICU admission requiring mechanical ventilation > 96 hours
planned discharge to home (self-care/carer)
willing and able to participate in exercise
deemed medically fit to take part in the intervention

Exclusion criteria

declined consent or unable to give consent
inability to participate due to e.g. any neurological, spinal or skeletal dysfunction affecting ability to exercise
cognitive impairment affecting ability to understand the intervention or complete questionnaires
participation in another rehabilitation programme due to ongoing chronic disease
other medical contraindication to participation in an exercise programme