Exercise and Colon Cancer

Abramson Cancer Center at Penn Medicine logo

Abramson Cancer Center at Penn Medicine

Status

Completed

Conditions

Stage II Colon Cancer
Stage III Colon Cancer

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT02250053
UPCC 10214

Details and patient eligibility

About

Despite the success of surgery and chemotherapy among people with colon cancer, 30-50% of patients develop recurrent disease. Physical activity has emerged as a potential lifestyle intervention to reduce cancer recurrence and improve survival among people with colon cancer (CC). This pilot study aims to identify the dose-response effects of aerobic exercise on molecular and cellular pathways associated with physical activity and CC outcomes among patients with stage II and III CC.

Enrollment

44 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • histologically confirmed TNM stage II-III CC;
  • completed surgical resection and adjuvant chemotherapy (if applicable) within 1-24 months before entering the study;
  • ≤120 min/wk of self-reported moderate or vigorous intensity physical activity using the Paffenbarger physical activity questionnaire;
  • age ≥18 years;
  • written physician approval;
  • no additional surgery planned within the 6-month intervention (including colostomy reversal);
  • ability to walk unaided for 6-minutes;
  • no contraindications to exercise using the PA readiness questionnaire (PAR-Q), unless physician approves participation with specific knowledge of this contraindication.

Exclusion criteria

  • history of another primary invasive cancer (other than non-melanoma skin-cancer);
  • evidence of metastatic CC (i.e., TNM M1);
  • planning to receive any additional adjuvant chemotherapy;
  • pregnant or breast feeding;
  • unable to provide baseline blood sample;

cardiac conditions, including the following:

  • myocardial infarction or coronary revascularization procedure within prior 3 months;
  • uncontrolled hypertension (systolic ≥180 mmHg or diastolic ≥100 mmHg);
  • high-risk or uncontrolled arrhythmias;
  • clinically significant valvular disease;
  • decompensated heart failure;
  • known aortic aneurysm;
  • any other condition that may impede testing of the study hypothesis or make it unsafe to engage in the exercise program (determined by the investigative team).

Trial design

44 participants in 1 patient group

exercise
Experimental group
Description:
aerobic exercise on soluble intercellular adhesion molecules
Treatment:
Other: Exercise

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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