Exercise and Flax-Based Nutritional Supplementation for Lowering Cholesterol

University of Saskatchewan

Status and phase: Completed; Phase 3

Conditions: Osteoporosis; Metabolic Syndrome

Treatments: Behavioral: Exercise (walking); Dietary Supplement: Flax lignan

Study type: Interventional

Funder types: Other

Identifiers

NCT00204412

686868

Details and patient eligibility

About

The purpose of our study is to use a flaxseed-based nutritional supplement in combination with exercise training (walking) for improving cholesterol levels. We hypothesize that exercise training will improve cholesterol profile and that adding supplementation with a flaxseed nutritional supplement will further improve cholesterol profile.

Full description

Flax supplementation and exercise training each have small beneficial effects for improving blood lipid profile and reducing cardiovascular disease risk. Flax lignan, a phytoestrogen found in flaxseed is thought to be the active compound responsible for the cholesterol-lowering effect of flaxseed. Our purpose is to combine an exercise training program (walking) with flax lignan supplementation for improving blood lipid profile.

Comparisons: Walking (6 days per week) plus flax lignan (500 mg per day) compared to walking plus placebo.

Enrollment: 100 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 50 years or older

Exclusion criteria

• Currently taking medication for cholesterol
• Smoker
• Diabetic
• Gastrointestinal disease
• Females on hormone replacement therapy
• Currently taking a flaxseed supplement
• Currently engaged in vigorous exercise training

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

flax lignan

Treatment:

Dietary Supplement: Flax lignan

Behavioral: Exercise (walking)

2

Placebo Comparator group

Description:

placebo

Treatment:

Dietary Supplement: Flax lignan