Exercise and Genes in Obese (EGO)

Jarle Berge

Status: Unknown

Conditions: Obesity

Treatments: Other: Training intensity intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT02311738

EGO

Details and patient eligibility

About

Regular exercise has several positive health effects including increased physical fitness and muscle mass. It is well known that increased muscle mass is associated with increased resting energy expenditure which may facilitate weight loss and maintenance. Previous studies have, however, failed to show any consistent association between the intensity of physical exercise and energy expenditure, or relate the variance in these adaptations to genetic variability. Whether high-intensity exercise (HIE) is associated with improved health related quality of life in severely obese patients remains unknown.

This PhD-project is based on a planned randomised controlled study including 50 or more treatment seeking morbidly obese patients who will be randomised to either a 24 week moderate-intensity exercise (MIE) programme or a 24 week high-intensity exercise (HIE) programme. The investigators main hypothesis is that patients randomised to the HIE-program will achieve higher energy expenditure during rest and physical activity after treatment than those allocated to the MIE-programme. In addition, the investigators hypothesise that the HIE-group will achieve a better health related quality of life than the MIE-group after treatment. The investigators also hypothesize that inter-individual variability in adaptation to the two training regimens may be due to genetic factors. If the investigators hypotheses are confirmed, this project might have beneficial clinical implications for future obesity treatment strategies.

Enrollment: 50 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Treatment seeking weight stable morbidly obese patients (BMI ≥ 40 kg/m2 or BMI 35 to 39.9 kg/m2 with ≥ 1 co morbidity) attending the outpatient Obesity Center, Vestfold Hospital Trust, will be informed about this RCT .

Exclusion criteria

• Uncompensated heart failure
• Recent myocardial infarction or stroke (<½ years)
• Severe arrhythmia or heart failure
• Unstable angina pectoris
• Renal failure
• Pregnancy
• Severe eating disorders
• Active substance abuse
• Being on a diet
• Taking medication known to affect appetite or metabolism (including thyroxin).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

High intensity training group

Experimental group

Description:

HIE will consist of the following: 1. 10 minute warm up at 70% of maximal heart rate. 2. 4 minute exercise intervals at 90-95% of maximal heart rate. 3. 4 minute interval bouts repeated 4 times. 4. Between each bouts there will be a 3 minute active recovery at 70% of maximal heart rate 5. After all four bouts are completed; 5 minute cool-down at 70% of maximal heart rate.

Treatment:

Other: Training intensity intervention

Moderate intensity training group

Experimental group

Description:

MIE will consist of the following: 1. 10 minute warm up at 50% of maximal heart rate. 2. 35 minutes exercise at 70% of maximal heart rate. 3. 4 minute cool-down at 50% of maximal heart rate.

Treatment:

Other: Training intensity intervention