Exercise and Glycemic Control in Type 2 Diabetes

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Hyperglycemia; Diabetes Mellitus, Type 2

Treatments: Behavioral: Exercise intervention; Behavioral: No exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00945165

09-3-028

Details and patient eligibility

About

Hyperglycemia is an independent risk factor for the development of diabetic complications in type 2 diabetes. Exercise improves glycemic control, however, the role of exercise characteristics (e.g. intensity, type of exercise, timing, frequency) remains to be elucidated.

This study aims to assess the effect of several exercise characteristics on hyperglycemia in various subgroups of type 2 diabetes patiënts.

Enrollment: 124 patients

Sex: Male

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Impaired glucose tolerant subjects

Inclusion Criteria:

• BMI 25 - 35 kg/m2
• Impaired Glucose Tolerant (according to ADA guidelines)

Exclusion Criteria:

• Cardiac disease (cardiac event in the last 5 years)
• Type 2 diabetes
• Use of orale blood glucose lowering medication or exogenous insulin
• HbA1c >10%

Insulin treated type 2 diabetes patients

Inclusion Criteria:

• BMI 25 - 35 kg/m2
• Insulin therapy
• diagnosed with type 2 diabetes >2 yr

Exclusion Criteria:

• Cardiac disease (cardiac event in the last 5 years)
• HbA1c >10%

Type 2 diabetes patients on oral blood glucose lowering medication

Inclusion Criteria:

• BMI 25 - 35 kg/m2
• diagnosed with type 2 diabetes >2 yr

Exclusion Criteria:

• Cardiac disease (cardiac event in the last 5 years)
• HbA1c >10%
• use of exogenous insulin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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124 participants in 2 patient groups

Exercise

Experimental group

Treatment:

Behavioral: Exercise intervention

No exercise

Experimental group

Treatment:

Behavioral: No exercise