Exercise and Mortality in Middle-Aged and Older Adults

City of Hope

Status

Begins enrollment in 1 month

Conditions

Overall Survival (All-cause Mortality)

Treatments

Behavioral: Control

Behavioral: Exercise

Study type

Observational

Funder types

Other

Identifiers

NCT07224659

25603

Details and patient eligibility

About

This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).

Enrollment

19,000 estimated patients

Sex

All

Ages

55 to 74 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Adults enrolled into the PLCO screening trial.
Among participants reporting low exercise at Q0 (i.e., 0 or less than 1 day/week, with each session <15 minutes in duration), completion of an exercise survey at Q1 as part of PLCO standard trial procedures no later than 5 years after reporting non-exercising status [i.e., no exercise) at Q0.
No evidence of any of the following absolute contraindications to exercise: uncontrolled hypertension, symptomatic valvular disease; hypertrophic cardiomyopathy; unstable angina pectoris; primary pulmonary hypertension; heart failure; severe arrhythmia; diagnosed dementia; any form of cancer other than non-melanoma, and severe infectious disease.