Exercise and Nerve Function in Diabetes

Patricia Kluding, PhD

Status: Completed

Conditions: Diabetic Neuropathy

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT00970060

11385

GCRC #105 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to describe the effect of a 10-week exercise program on nerve function and number of nerve fibers in the skin in the lower leg in people with diabetic neuropathy.

Full description

The objective for this application is to quantify the benefits of exercise on nerve function including proprioception, and investigate the relationship of these findings with improvements in epidermal and dermal innervation. In this pilot project, we will pursue 2 specific aims: 1) determine the effect of an exercise intervention on nerve function in people with diabetic neuropathy, and 2) assess changes in cutaneous innervation following participation in an exercise program.

Enrollment: 26 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 40-70
• Type 2 diabetes
• Peripheral neuropathy

Exclusion criteria

• Serious cardiac history or other medical problems that would prevent safe participation in exercise

Trial design

26 participants in 1 patient group

Exercise program

Experimental group

Description:

Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.

Treatment:

Behavioral: Exercise