Exercise and Nutrition Interventions in Age-related Sarcopenia

Liverpool Hope University

Status: Unknown

Conditions: Sarcopenia; Muscular Atrophy

Treatments: Dietary Supplement: Protein Supplementation; Other: Aerobic Exercise; Other: Resistance Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02912130

LiverpoolHU

Details and patient eligibility

About

This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life in Age-related Sarcopenia.

Full description

Musculoskeletal ageing is an inevitable process associated with profound morphological and functional changes that will ultimately transition an individual from independent, to dependable living, relying heavily on personal health care for survival. The United Kingdom (UK) population aged over 65 years is expected to rise from 8.8 to 11.3 million by 2025. As life expectancy increases due to advances in medical treatment, an age-related disease termed sarcopenia, has become more prevalent in the elderly. Sarcopenia, described as the loss of musculoskeletal mass, strength and/or physical functioning with age, manifests after the 6th decade and rapidly increases after the 8th decade, resulting in a deterioration of health status and quality of life. To manage the looming health and economic consequences of sarcopenia, suitable therapeutic strategies to manage the condition are warranted. Therefore, this randomised control trial (RCT) will investigate the effects of 16-weeks of exercise and nutritional interventions in inactive senior citizens (60 - 90 years old).

Enrollment: 160 estimated patients

Sex: All

Ages: 60 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male and Female participants
• 60 - 90 years of age
• Resident in North West, England, UK
• BMI 18.5-30 kg/m
• Can speak and understand English
• Willing to consent and follow the study procedures

Exclusion criteria

• Recent (i.e. past 3 months) or concurrent participation in any clinical trial or dietary and/or exercise intervention program
• Self-reported lactose intolerance
• Uncontrolled diabetes (HbA1C >10)
• Uncontrolled Hypertension (160/100) and uncontrolled hypotension (<100 systolic)
• Treatment with Beta Blockers, Calcium Channel Blockers, Digitalis, Bronchodilator,
• Diuretics, Vasodilators
• Current hormone therapy such as insulin, testosterone or hormone replacement therapy
• History of falls/osteoporosis
• Major psychological/mental illness
• Medical conditions that precluded safe participation in an exercise program
• Other major systemic diseases: Liver and kidney diseases, Advanced gastrointestinal disorders, Cardiovascular Diseases, Advanced chronic obstructive pulmonary disease, Advanced Rheumatoid Arthritis, Cancer

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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160 participants in 4 patient groups

Control

No Intervention group

Description:

No Intervention

Exercise

Experimental group

Description:

1. Aerobic Exercise i.e. 30-60 minutes per week of moderate intensity exercise 2. Resistance Exercise i.e. 60 minutes per week of progressive resistance training

Treatment:

Other: Resistance Exercise

Other: Aerobic Exercise

Exercise+Nutrition

Experimental group

Description:

1. Aerobic Exercise i.e. 30-60 minutes per week of moderate intensity exercise 2. Dietary Supplement i.e. Protein Supplementation 1.2-1.5g/kg/body weight per day

Treatment:

Other: Resistance Exercise

Other: Aerobic Exercise

Dietary Supplement: Protein Supplementation

Nutrition

Experimental group

Description:

Dietary Supplement: Protein Supplementation i.e. 1.2-1.5g/kg/body weight per day

Treatment:

Dietary Supplement: Protein Supplementation