Exercise and Overnight Motor Sequence Task (EOMST)

The University of Hong Kong (HKU)

Status: Completed

Conditions: Psychotic Disorders; Schizophrenia and Related Disorders

Treatments: Other: Non-exercise; Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03800368

HKU_Psych

Details and patient eligibility

About

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

Enrollment: 51 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged from 18 to 55
• Based on the SCID diagnosed to have schizophrenia and related psychotic disorders
• Ability to understand the nature of the study and to give written informed consent

Exclusion criteria

• Severe physical illness (Myocardial Infarction, Hypertension, Fracture, Spinal problems in which exercise may be contraindicated), and seizure disorders
• Comorbid substance dependence
• Unstable psychotic symptoms
• A history of brain trauma or organic brain disease
• Known history of intellectual disability or special school attendance
• Answered one or more "yes" in the PAR-Q and without doctors approval for exercise

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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51 participants in 3 patient groups

High-endurance group

Experimental group

Description:

This group of subjects will receive 2-3 sessions of high-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will interchange between the aerobic and anaerobic state.

Treatment:

Other: Exercise

Low-endurance group

Experimental group

Description:

This group of subjects will receive 2-3 sessions of low-intensity cycling exercise training per week, for a total of 12 weeks. The exercise the subjects received will maintain at an aerobic level.

Treatment:

Other: Exercise

Psycho-education

Active Comparator group

Description:

This group of subjects will receive 2-3 sessions of psycho-education class per week, for a total of 12 weeks. The content of the class includes non-exercise related psycho-education content to participants (e.g., food hygiene, psychological well being, food nutrition, etc).

Treatment:

Other: Non-exercise