Exercise and Pain Sensitivity in Knee Osteoarthritis

Frederiksberg University Hospital

Status

Completed

Conditions

Knee Osteoarthritis

Treatments

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT01545258

PI101.03

Details and patient eligibility

About

A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability.

While the link between exercise and reduced disability is mediated by e.g. increased muscle strength and endurance, the analgesic mechanisms related to exercise are unexplored. knee OA patients have both peripheral and central sensitization of pain mechanisms resulting in hyperalgesia. Thus, targeted pain treatment in these patients may focus on both peripheral and central mechanisms but it unknown if exercise affects either of these mechanisms.

It is hypothesized that in knee OA patients exercise reduces the pain sensitivity

Enrollment

60 patients

Sex

All

Ages

40+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age above 40 years
Clinical diagnosis of tibiofemoral osteoarthritis
Radiographic verification of diagnosis (Kellgren&Lawrence 2 or 3)
Ability to participate in examinations
Ability to participate in exercise sessions
20≤ Body Mass Index (BMI) ≤35 kg/m2
Ability to comply with rules about concomitant medication and therapy
Speak, read and write Danish

Exclusion criteria

Participation in exercise training for the knee osteoarthritis within 3 months of enrollment
Counterindications for exercise
Pregnant or breastfeeding
Current or previous autoimmune disease
History of surgical joint replacement in the lower limbs
Planned surgery
Current or previous diagnosis or signs of cardiovascular disease
Neurological disorders
Alcohol or drug abuse
Diabetes
Psychiatric disorders
Regional pain syndromes
Regional pain caused by lumbar or cervical nerve root compression
Counterindications to MR scan
Counterindications to MR contrast