Exercise and PRP vs Exercise Alone in Patients With Knee Osteoarthritis

Istanbul University - Cerrahpasa (IUC)

Status

Completed

Conditions

Knee Osteoarthritis

Treatments

Biological: PRP

Other: Exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT04697667

TDK-2020-35062

Details and patient eligibility

About

This study is a prospective randomized controlled study of different treatments for knee osteoarthritis and aims to investigate the efficacy of exercise combined platelet rich plasma (PRP) injection versus only exercise or only PRP treatments.

Enrollment

84 patients

Sex

All

Ages

40 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adults 40-70 years of age,
Grade 2-3 according to Kellgren Lawrence osteoarthritis classification,
No medication for knee osteoarthritis in the past three months,
Subjects who understand and sign the consent form for this study.

Exclusion criteria

Patients who have received an invasive procedure, intra-articular application and / or physiotherapy in the target knee within three months,
Previous partial or total knee replacement of the target knee,
Body mass index > 30 kg/m2,
Having any cardiovascular diseases, neurological disorders, rheumatic diseases, malignancy or psychiatric diseases,
Impaired cognition that impacts the ability to give informed consent,
Participation in another clinical trial.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

84 participants in 3 patient groups

Group I

Experimental group

Description:

Each subject in this group will receive a combined treatment protocol consisting of three PRP injections to knee joint and supervised exercise program.

Treatment:

Biological: PRP

Other: Exercise

Group II

Active Comparator group

Description:

Each subject in this group will receive a treatment of supervised exercise program.

Treatment:

Other: Exercise

Group III

Active Comparator group

Description: