Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population (ExAMIN AGE)

University of Basel

Status: Completed

Conditions: Heart; Disease, Activity; Obesity; Atherosclerosis; Cardiovascular Disease

Treatments: Other: Training or control condition

Study type: Interventional

Funder types: Other

Identifiers

NCT02796976

EKNZ-2015-351

Details and patient eligibility

About

The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed. In the interventional approach (Part II), it aims to investigate whether and to what extent advanced vascular ageing (AVA) in older subjects with increased cardiovascular risk can be reversed by regular walking- based high intensity interval training.

Full description

In the cross-sectional part the investigators analyze physical fitness, vascular health and further outcomes in a healthy older active, a healthy older sedentary and a obese sedentary group with increased cardiovascular risk. The investigators will analyze large and small artery function, physical fitness and activity as well as inflammatory parameters in these three groups. Here the investigators will investigate the influence of physical activity and inflammatory parameters on the vascular health in different beds.

In the intervention part the older sedentary group with increasing cardiovascular risk (OSR) will be randomized in a control and an intervention group. The intervention group will get a high intensity interval training which is walking based and individual adjusted. The control group will get general lifestyle recommendations. After 12 weeks of training OSR group will be tasted again. The aim of the second part is to assess the effect of high intensity interval training on vascular health and inflammatory parameters.

Enrollment: 158 patients

Sex: All

Ages: 50 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men and women aged 50-79 years
• Active lifestyle: > 9 MET/week (> 3hours moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
• Sedentary lifestyle: ≤ 3 MET/week (≤ 1 hour moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2
• Sedentary men and women aged 50-79 years with increased cardiovascular risk are allowed to have ≥ one additional cardiovascular risk factor

Exclusion criteria

• History of cardiovascular, pulmonary or chronic inflammatory disease
• blood pressure ≥ 140/90 mmHg during 24h monitoring
• current or past smoker (in healthy group)
• macular degeneration or glaucoma
• compromising orthopaedic problems

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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158 participants in 3 patient groups

healthy older active

No Intervention group

Description:

only cross-sectional

healthy older sedentary

No Intervention group

Description:

only cross-sectional

older sedentary at risk

Active Comparator group

Description:

cross-sectional and training or control condition

Treatment:

Other: Training or control condition