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Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease

E

East Tennessee State University

Status

Completed

Conditions

Heart Diseases

Treatments

Other: Exercise training

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

A before and after study involving 43 adult subjects at risk of having ischemic heart disease. Subjects underwent 6 months of supervised moderate intensity aerobic and resistive exercise training. Blood samples were obtained at entry and at 6 months for measurement of complement (C3), CRP, blood lipid levels, lymphocyte phenotypes, and for the isolation, culture, and measurement of the spontaneous and phytohemagglutinin-induced secretion of proatherogenic and antiatherogenic cytokines by their peripheral blood mononuclear cells (PBMC).

Full description

A before and after study involving 43 adult subjects at risk of having ischemic heart disease. Subjects underwent 6 months of supervised moderate intensity aerobic and resistive exercise training. Blood samples were obtained at entry and at 6 months for measurement of complement (C3), CRP, blood lipid levels, lymphocyte phenotypes, and for the isolation, culture, and measurement of the spontaneous and phytohemagglutinin-induced secretion of proatherogenic and antiatherogenic cytokines by their peripheral blood mononuclear cells (PBMC

Enrollment

52 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • normal EKG
  • normal stress test

Exclusion criteria

  • abnormal EKG
  • abnormal stress test
  • presence of a chronic inflammatory disease
  • presence of malignancy
  • immunosuppressive therapy

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

52 participants in 1 patient group

Exercise
Experimental group
Description:
6 moths of supervised moderate intensity aerobic and resistive exercise training
Treatment:
Other: Exercise training

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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